Dr. Denese SkinScience HydroShield Ultra Moisturizing Face Serum 4 oz – Retinol & Ceramide Formula for Deep Moisture, Smooth Radiant Skin, Fine Line Care – Dermatologist-Tested & Cruelty-Free

Price: $110.00
(as of Mar 10, 2026 23:20:24 UTC – Details)

Product description

Our Hydroshield hydrating serum that locks in moisture to drastically reduce the look of dry lines and wrinkles and to plump the appearance of the skin. In fact, an independent clinical study, using a scientific instrument to measure the level of hydration in the skin, found that our Hydroshield Serum increased the level of skin hydration by 184% in just 15 minutes. Not surprisingly, Hydroshield has a dramatic visual impact on the appearance of dry lines, almost immediately. It intensely moisturizes skin for a soft, supple, luminous, youthful look. So, if your skin feels dry by midday, if you see more dry lines around the eyes and cheeks each and every year, you need our Hydroshield.

Usage: In the morning and evening, apply to clean face before your day cream or night cream. Let the serum penetrate for five to seven minutes, until it turns matte. If you are oily or normal, apply only around the eyes, cheeks and neck. Even if you are oily, the eye area skin is almost always dry.

Who is it for:

Suitable for any skin types from dry to normal, in order to dramatically and almost immediately change the look of dry lines. If your skin is oily, place it only around the eyes and neck and on dry patches–not on the oily T-zone. Our Hydroshield Serum is remarkably effective for dry lines and wrinkles, as it locks in hydration and increases hydration on average, by 184% in only 15 minutes in order to recreate the youthful, plump look of young skin.

Why is it different:

Our Hydroshield Serum is based on years of medical research that identified a unique and proprietary technology that we named Hydroshield Technology, that uses lipids that are virtually identical to the skin’s own lipids. As we age, skin lipids decline, leaving the skin dry and line prone. Our proprietary Hydroshield Technology supplies a balance of skin identical lipids, ceramides and Essential Fatty Acids to help the skin lipid barrier to function at a much younger level. Once hydration and moisture is locked into the skin, the appearance of dry lines and wrinkles improve rapidly.

Research Results: 184% increase in skin hydration after 15 minutes, as measured by a clinical instrument100% of subjects reported: skin hydration drastically improved100% of subjects reported: dry lines and wrinkles appear significantly reduced*100% of subjects reported: wrinkles appear drastically reduced100% of subjects reported: facial lines to look remarkably better

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Independent Clinical Study results after 21 days of product use Made without parabens or dyes. No animal testing.

A supercharged hydrating serum that locks in moisture to drastically reduce the look of dry lines and wrinkles. It intensely moisturizes skin for a soft, supple, luminous, more youthful look.

Remember: Dry skin equals wrinkled skin. Hydrated skin equals plump, dewy, youthful looking skin.

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Customer Reviews

4.5 out of 5 stars 180

4.6 out of 5 stars 1,030

4.4 out of 5 stars 37

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4.4 out of 5 stars 109

4.6 out of 5 stars 290

Price

$22.00$22.00
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$99.00$99.00
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Regimen Step
1. Cleanse and Tone 2. Exfoliate and Purify 3. Stimulate Cellular Performance 4. Build Lipid Barrier 5. Seal and Maintain 6. Protect and Correct

Benefit
Deep cleans, doesn’t leave your skin feeling tight and dry. Exfoliates, helps with lines, wrinkles, uneven skin tone and enlarged pores. Soften the look of lines and wrinkles. The skin-building phase helps restore skin barrier functions via delivering essential nutrients to the skin. Moisturizes and prevents water loss by sealing the skin. Protect skin from sun damage and future lines and wrinkles.

About Dr. Denese

One of the first doctors to specialize in anti-aging medicine, creator of Dr. Denese SkinScience, and a top-seller on QVC. Dr. Denese has made it her life’s mission to help women look younger, feel younger and live healthier lives. As an accomplished doctor, businesswoman and skin care visionary, Dr. Denese has connected directly to customers through her PBS Special and infomercial, giving all women access to her innovative, premium products at affordable prices. Dr Denese understands that to make skin look and feel young again, potent levels of scientifically-advanced ingredients are necessary for achieving visible results.

“My passion for making women feel beautiful and confident started at an early age.” – Dr. Adrienne Denese

Our brand has been certified by PETA as cruelty-free since August 3, 2017.

The Best Clinically-Studied, Anti-Aging Ingredients 100% experienced visibly improved texture 100% experienced brighter, more luminous skin 100% experienced more hydrated skin

Is Discontinued By Manufacturer ‏ : ‎ No
Product Dimensions ‏ : ‎ 3 x 2 x 9 inches; 4 ounces
Item model number ‏ : ‎ 809146
UPC ‏ : ‎ 811684022703
Manufacturer ‏ : ‎ Dr. Denese
ASIN ‏ : ‎ B004GLPUF4
Best Sellers Rank: #37,882 in Beauty & Personal Care (See Top 100 in Beauty & Personal Care) #794 in Facial Serums
Customer Reviews: 4.6 4.6 out of 5 stars (865) var dpAcrHasRegisteredArcLinkClickAction; P.when(‘A’, ‘ready’).execute(function(A) { if (dpAcrHasRegisteredArcLinkClickAction !== true) { dpAcrHasRegisteredArcLinkClickAction = true; A.declarative( ‘acrLink-click-metrics’, ‘click’, { “allowLinkDefault”: true }, function (event) { if (window.ue) { ue.count(“acrLinkClickCount”, (ue.count(“acrLinkClickCount”) || 0) + 1); } } ); } }); P.when(‘A’, ‘cf’).execute(function(A) { A.declarative(‘acrStarsLink-click-metrics’, ‘click’, { “allowLinkDefault” : true }, function(event){ if(window.ue) { ue.count(“acrStarsLinkWithPopoverClickCount”, (ue.count(“acrStarsLinkWithPopoverClickCount”) || 0) + 1); } }); });
DEEP, LONG-LASTING MOISTURE: This retinol face serum with ceramides and hyaluronic acid delivers intensive, lasting hydration that helps plump and smooth dry or mature skin, revealing a supple, radiant glow and silky texture all day long.
HELPS IMPROVE THE LOOK OF AGING SKIN: A targeted blend of retinol, peptides, and antioxidants supports smoother texture, elasticity, and tone, helping refine fine lines and leaving skin soft, luminous, and visibly refreshed for a youthful appearance.
BARRIER SUPPORT + RADIANCE: Formulated with ceramides and botanical extracts that reinforce the skin’s moisture barrier to defend against dryness, dullness, and environmental stress while promoting balanced hydration and a luminous, even-toned glow.
LIGHTWEIGHT, MAKEUP-READY TEXTURE: Fast-absorbing, non-greasy, and silky, this moisturizing serum layers seamlessly under sunscreen or foundation without residue, leaving skin smooth, supple, and perfectly prepped for effortless makeup application.
DOCTOR-DEVELOPED, LUXURY-PERFECTED: Created by Dr. Denese, this dermatologist-tested formula blends proven ingredients with indulgent texture to help improve the look of firm, radiant, hydrated skin—uniting science, care, & confidence in every drop.